Culmorin inhibits detoxification of the mycotoxin deoxynivalenol by plant UDP-glucosyltransferases
Herbert Michlmayr·Gerhard Adam·Rudolf Krska·Franz Berthiller·Johannes Weber·Gerlinde Wiesenberger·Marta Magdalena Sopel·Katrin Rehak·Philipp Fruhmann·Alexandra Malachová·Kristina Funtak·Marie Dufresne
The Fusarium metabolite culmorin (CUL) frequently co-occurs with the mycotoxin deoxynivalenol (DON) on cereals. While DON is recognized as a major Fusarium virulence factor on plants, the function of CUL is still unclear. Herein, we show that CUL-deficient F. graminearum mutants created by CLM1 deletion are less aggressive on wheat than the wild-type, accompanied by increased DON-3-glucoside/DON ratios in infected wheat ears. In root elongation assays with wheat and Brachypodium distachyon, CUL