Mitochondria are essential organelles in eukaryotic cells, enclosed by two membranes with distinct compositions and functions. In addition to the endoplasmic reticulum, mitochondria are major sites of cellular lipid production. Cardiolipin, for example, is exclusively synthesized in the mitochondrial inner membrane. This requires the precursor lipid phosphatidic acid to be imported from the endoplasmic reticulum to the mitochondrial outer membrane. Subsequently phosphatidic acid is transferred t
Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers
Fereshteh Sadeqi·Michael Meinecke·J. Metz·Dietmar Riedel·Andreas Janshoff·Herre Jelger Risselada·Caroline Kolenda·Kai Steffen Stroh·Dexin Dong·Marian Vache
