Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle
Chad Skiles·Micah J. Drummond·Ryan M. O'Connell·Zachary J. Fennel·Robert J. Castro·Elena M. Yee·Hannah A. Zabriskie·Mark A. Supiano·Paul‐Emile Bourrant·Melina Itinose
Immune cells are critical for modulating inflammation and extracellular matrix remodelling for effective muscle regrowth following disuse atrophy. However, disrupted macrophage function and accumulation of cellular senescence may limit muscle recovery in ageing. The present study aimed to compare changes in the cellular dynamics of muscle macrophages, cellular senescence and collagen content during early recovery following 14 days of unilateral limb immobilization in young (n = 18; ∼24 years) an