Fabrication and Characterization of Nerolidol-Based Invasomes: Loading, Stability and Antimicrobial Applications
Gaetano Lamberti·Anna Angela Barba·Diego Caccavo·Lorenzo Bosio·Dante Greco·Clotilde Silvia Cabassi·Nicolò Mezzasalma·Federico Righi·Marica Simoni·Costanza Spadini·Susanna Bosi·Sara Guarino·Raffaella De Piano
Background/Objectives: Nerolidol (NER) is a sesquiterpene alcohol with recognized antimicrobial potential, whose applications as a pure substance are limited by hydrophobicity, instability, and cytotoxicity. Invasomes, i.e., liposomes with terpene ingredients, offer a strategy to improve their delivery; however, the NER loading limits compatible with vesicle integrity are still unclear. Here, Nerolidol-loaded invasomes were produced using a controlled simil-microfluidic coaxial injection process