Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease
Hemanth R. Nelvagal·Zane Jaunmuktane·Toby J Curless·Patrick W. Cullinane·Alice Rockliffe·Samarth Pimparkar·Haruka Kawamura·Sophie Ollerenshaw·Isha Elahi·Sebastian Brandner·Lesley Wu·Raquel Real·Mina Ryten·John Hardy·Eduardo de Pablo Fernández·Thomas T. Warner·Huw R Morris·Yau Mun Lim·Nancy Chiraki
Dementia in Lewy body diseases (LBD) is common and arises through heterogeneous and incompletely understood pathways. Evidence suggests contributions from genetic factors, including APOE ε4 genotype, co-pathology including concomitant Alzheimer's disease pathology and hypoperfusion related to orthostatic hypotension. However, the relative impact of these factors remains unclear. To address this, we analysed 399 post-mortem brains from LBD cases comprising Parkinson's disease, Parkinson's disease