Seed germination is a critical agronomic trait for direct-seeding cultivation in rice. While maintaining reactive oxygen species (ROS) homeostasis is essential for this process, the underlying molecular mechanisms remain largely unknown. Here, we reveal that the OsNAC3-OsITPK4-OsMT2b module regulates seed germination by modulating ROS homeostasis. In this module, OsITPK4, a member of the inositol 1,3,4-triphosphate 5/6-kinase family, is specifically induced during seed germination and functions