Bacterial resistance has become a critical global health threat, demanding innovative non-antibiotic strategies. Coordination-driven self-assembly provides a powerful approach for constructing metal-organic macrocycles and cages (MOMs/MOCs) with precisely defined cavities, tunable charge distributions, and multifunctional surfaces. These supramolecular architectures exhibit potent antibacterial activity through dual mechanisms: (i) electrostatic and hydrophobic disruption of bacterial membranes