Multi-Antibiotic Porous Systems for Tailored Drug Delivery in Dentistry: Formulation Strategy, Physicochemical Properties, and Release
Monika Biernat·Dorota Olczak-Kowalczyk·Krzysztof Adam Stępień·Joanna Giebułtowicz·L. Ciołek·Piotr Szterner·Paulina Tymowicz-Grzyb·Bartosz Kózka·Anna Sylla
Background/Objectives: Although triple antibiotic paste is effective in managing infected primary teeth, its incomplete removability from tooth structure remains a major limitation, prompting the search for alternative drug-delivery systems. The aim of this study was to obtain a multi-antibiotic porous composite system for tailored drug delivery, to develop a formulation strategy, and to characterize the physicochemical properties and drug release. Methods: The developed composites consisted of