Inverted Alu repeats in loop-out exon skipping across hominoid evolution

Changes in RNA splicing over the course of evolution have profoundly diversified the functional landscape of the human genome. Emerging evidence suggests that inverted pairs of intronic Alu elements can promote exon skipping by forming RNA stem-loop structures. However, their prevalence and influence throughout evolution remain unknown. Here, we present a systematic analysis of inverted Alu pairs across the human genome to assess their impact on exon skipping and their relevance to hominoid evol