Silver catalysed asymmetric [3+2] cycloaddition for the construction of 5−5-membered 1,3'-indolyl pyrrole atropisomers

An atropoenantioselective Ag-catalysed [3+2] cycloaddition of N-alkynyl ketones with isocyanides has been developed to access 5−5-membered 1,3'-indolyl pyrroles bearing C-N axial chirality in high yields and excellent enantioselectivities. The resulting...