Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study
Stella Wolfgruber·Mario Tumbarello·Sarah Sedik·Jon Salmanton-García·Sevtap Arikan-Akdagli·J. P. Gangneux·Riina Rautemaa-Richardson·Valentina Arsić-Arsenijević·Sonia Martín-Pérez·Julio Dávila·Nurettin Erben·Emin Halis Akalin·Lubos Drgona·Cornelia Lass-Flörl·Julio Alberto García-Rodríguez·Tihana Bicanic·Helena Hammarström·Petr Hamal·Jörg Steinmann·E. W. Meijer·Nina Khanna·Guillaume Désoubeaux·Thomas Longval·Uluhan Sili·Janina Trauth·Matteo Bassetti·P Lewis White·Avinash Aujayeb·Tadeja Matos·Deniz Akyol·François Danion·Katrien Lagrou·Benedict Rogers·Maite Ruíz·Alena Siváková·Malgorzata Mikulska·Michael Samarkos·Ola Blennow·Deborah Lockhart·Blandine Denis·B. Willinger·Karin van Dijk·Ulrike Scharmann·Anna L. Goodman·Jens Van Praet·Manjusha Narayanan·Cristina Toscano·Laura Loughlin·Nick de Jonge·Alba Ruiz-Gaitan·Fanny Lanternier·Juergen Prattes·Emmanuel Roilides·Alida Fe Talento·Aleksandra Barać·Matthias Egger·Maiken Cavling Arendrup·Philipp Koehler·Oliver A Cornely·Martin Hoenigl·ECMM Candida III Study Group·Murat Akova·Christoph Zurl·Igor Stoma·Alpay Azap·Johanna Kessel·Zdenek Racil·Lucia Taramasso·Anna Maria Peri·Matjaž Jereb·Özge Turhan·Nikolai Klimko·Maria Calbacho·C García-Vidal
Abstract The European Confederation of Medical Mycology Candida III was a pan-European, multicenter observational study of adult patients with blood culture–proven candidemia. Among a total of 632 patients with candidemia across 64 institutions in 20 European countries, a subanalysis of 396 (63%) cases occurring outside the intensive care unit (ICU) was conducted. Compared with ICU patients, non-ICU patients had a higher comorbidity burden (median Charlson comorbidity index [CCI] 6 vs 5 in ICU p