Abstract Background: Schizotypy is a key risk factor for psychosis-like experiences and for identifying those at high risk for schizophrenia spectrum disorders. However, there is little research on schizotypy measures among people who use substances. This study examined the validity of the Oviedo Schizotypy Assessment Questionnaire-Abbreviated (ESQUIZO-Q-A) in adolescents and young adults who use substances. Methods: A total of 4,360 participants who reported alcohol, tobacco, or cannabis use in