Although it is well-established that stem cells maintain tissue homeostasis while tumors disrupt it, the mechanisms by which tumors influence the development of nearby stem cells remain poorly understood. Using Drosophila ovaries as a model system, here we discovered that bam or bgcn mutant germline tumors inhibit the differentiation of neighboring wild-type germline stem cells (GSCs). Mechanistically, these tumor cells mimic the stem cell niche by secreting the BMP ligands Dpp and Gbb, but at r
Tumors mimic the niche to inhibit neighboring stem cell differentiation
Yang Zhang·Shaowei Zhao·Jinqiao Song·Lizhong Yan·Ziguang Wang·Dan Song·Hao Wang·Shuo Yang·Liyuan Niu·Chang Sun·Heng Zhang·Yudi Zhao·Yuejia Wang
