NT-I7, a long-acting interleukin-7, increases lymphocyte counts and induces CD8+ T cell clonotype expansion in patients with newly diagnosed high-grade gliomas
Omar H. Butt·Jian L. Campian·Jingqin Luo·Michael P. Rettig·Jennifer A. Foltz·Jiayi Huang·Alice Y. Zhou·Yu Tao·Obi L. Griffith·Malachi Griffith·Tanner M. Johanns·George Ansstas·Chaocai Zhang·Justin Tang·Stephanie Christ·Sara Ferrando-Martinez·Byung Ha Lee·John F. DiPersio·Milan G. Chheda·Todd A. Fehniger·Kartik Singhal
NT-I7 has the potential to maintain and increase lymphocyte counts in HGG patients and warrants further investigation, particularly in combination with immune-based therapies.