The Impact of Adopting Whole Genome Sequencing for Tuberculosis Diagnosis in China: A Cost-Effectiveness Analysis
Y Yiannian He·Yan Li·Dan Xu·Jiajun Yuan·Chang Liu·Bonan Fan·Yang Yang·J R Colón Pagán·Stella Wong·Xuanjing Li
Abstract Background China is a high-burden tuberculosis (TB) country and delays in diagnosis and effective treatment have further exacerbated this situation. Whole genome sequencing (WGS) has emerged as a reliable approach for drug susceptibility testing (DST) in TB. WGS can improve TB treatment outcomes but also requires significant investments in laboratory infrastructure and trained personnel. It is unclear whether WGS is a cost-effective strategy for routine TB diagnosis in China. Methods We