The choroid plexus: both a gatekeeper and a conductor of neuroimmune communication

The choroid plexus (ChP) is increasingly recognized as a dynamic neuroimmune interface that integrates peripheral and central signals to regulate cerebrospinal fluid (CSF) homeostasis, leukocyte trafficking, and inflammatory tone within the central nervous system (CNS). Recent studies reveal that beyond their classic roles in CSF production and barrier function, ChP epithelial cells are conductors of neuroimmune communication, actively remodeling the state of immune activity, immunosurveillance