Time Course of the Immune Response in a Preterm Infant With Congenital Syphilis Following Incomplete Maternal Treatment: A Case Report
Motomichi Nagafuji·Hidetoshi Takada·Takashi Matsumoto·Satoshi Fujiyama·Anri Amano·Naoko Morishima·Yuto Tanaka·Yuki Okada·Yuri Nakamura·Shusuke Takeuchi·Yu Kanai·Makoto Saito·Yayoi Miyazono·Miyuki Mayumi·Hiromi Hamada·Daisuke Hitaka
To the Editors: Rising maternal syphilis infections have led to a surge in congenital syphilis (CS), which causes severe and permanent health issues leading to substantial social and economic burdens compared with adult infection.1,2 However, the immunopathogenesis of CS, especially the role of neonatal immunity, remains unclear. Here, we report a case of a preterm infant with CS following incomplete maternal treatment, providing a unique opportunity to observe fetal–neonatal immune responses to