Beyond Candida: Life-threatening Disseminated Blastomycosis in Pediatric STAT1 Gain-of-Function Disease

To the Editors: Signal transducer and activator of transcription-1 gain-of-function (STAT1 GOF) mutations are classically recognized through chronic mucocutaneous candidiasis (CMC), reflecting impaired T helper (Th)17 differentiation and reduced interleukin (IL)-17-mediated antifungal immunity.1–3 However, increasing clinical experience demonstrates that the infectious phenotype extends beyond Candida, encompassing viral, bacterial and invasive fungal pathogens.2,4 This broader susceptibility is