Neuroprotective Role of Nrf2 Activation Against ER Stress–Mediated Apoptosis in Obstructive Sleep Apnea
PeiPei Zhong·Xiaohong Cai·Yang Ke·Xiucui Li·Jie Liu·Yuesha Pan·Youliang Xu·Chenyi Yu·Tong Wu·Tsague Mbiada Meffo·Shurui Zhuge·Qiuyan Xue·Jiaqi Li·Fei Gao·Xuanhao Peng·Liujia Xu·Yunjia Tu·Weikun Zheng
Obstructive sleep apnea (OSA) induces childhood cognitive impairment via chronic intermittent hypoxia (CIH), a process to which endoplasmic reticulum stress (ERS)-mediated apoptosis critically contributes. Nuclear factor erythroid 2-related factor 2 (Nrf2) is widely recognized for its significant neuroprotective effects in various neurological diseases, yet its role in ERS-related apoptosis in prefrontal neurons under CIH remains unclear. This study investigated Nrf2's impact both in vitro and i