Tau pathology in epilepsy: emerging mechanisms and translational opportunities
A. K. Sen·Terence J. O'Brien·Aristea S. Galanopoulou·Maria Thom·M Koepp·Christoph Helmstaedter·Lucy Vivash·A. Amos·M. Hardmeier·Stephan Rüegg·Yaroslav Winter·Hilal A Lashuel·Eleonora Aronica·Xin You Tai·Jeffrey L. Noebels
The onset of epilepsy in adulthood occurs most commonly after 55 years of age. Given the ageing global population, this disorder represents an increasing burden on healthcare and society. The bidirectional link between epilepsy and dementia is a focus of intense research with underlying tau pathology highlighted as a potential mechanistic link. In this review, we examine the evidence for tau-related neurodegenerative processes in epilepsy beginning with how changes in biochemical and structural