Pancreatic Cancer Detection Consortium Biomarker Bakeoff: A Phase 2 blinded biomarker validation and panel discovery study
Ann L. Oberg·Michael G. Goggins·Grant Izmirlian·Seetharaman Balasenthil·Surinder K. Batra·Masataka Hayashi·Daniel S. Herman·Michael A. Hollingsworth·Maneesh Jain·Ann M. Killary·Brianna M. Krusen·Suyu Liu·Shounak Majumder·Gopalakrishnan Natarajan·Subrata Sen·Lynette M. Smith·S. K. Srivastava·Brian M. Wolpin·Ken Zaret·William R. Bamlet
The CA19-9/FUT2/3 panel was the best performing panel in this biomarker bakeoff. Its evaluation in larger studies is warranted. Biomarker bakeoffs are an effective strategy for comparing the performance of promising biomarkers for pancreatic cancer early detection, and the PCDC is well poised to conduct such studies. Recommendations for performing such studies are provided.