Membrane-Based Assembly and Interactions in Immune Receptors

Immune receptors are modular sensors that detect molecular changes indicating infection, cell/tissue damage, oncogenic transformation, or exposure to allergens, and the signals they transmit initiate and regulate immune responses. These transmembrane receptors are often composed of one or more single-spanning membrane proteins and are modular in two important aspects. First, many immune receptors assemble from ligand-binding modules and signaling modules made up of separate proteins that come to