TThe Cerebellum3/23/2026

Effective Connectivity Identifies Divergent Cerebro-Cerebellar Network Organization in Schizophrenia

Introduction functional impairments in schizophrenia may arise from disruptions in large-scale brain networks. Emerging evidence highlights the cerebellum's role in cognitive and affective regulations, yet its directional influence remains poorly understood. This study examines effective connectivity (EC) within cortico-striato-cerebellar networks in schizophrenia and healthy adults. Methods resting-state functional magnetic resonance imaging data from the Centers of Biomedical Research Excellen