KR-62980, a novel PPARγ agonist, inhibits collagen-induced platelet activation and thrombus formation by regulating the GPVI signaling pathway
Su Bin Wang·Tong-Shin Chang·Taeryeong Kim·Pyeongkeun Kim·Eun Bee Oh·Jisue Sohn·Jin Hee Ahn·Ji Won Park·Solee Kim
Pathological platelet activation is central to cardiovascular disorders. Glycoprotein VI (GPVI), a pivotal collagen receptor, is a promising antithrombotic target. While earlier studies focused on the downstream effects of peroxisome proliferator-activated receptor γ (PPARγ) ligands, we recently identified the proximal PPARγ-Src family kinase (SFK) interaction as a key regulatory node. KR-62980 is a novel non-thiazolidinedione (non-TZD) PPARγ modulator designed to minimize traditional TZD-associ