Compensatory and Dynamic Cerebellar Responses to Striatal Lesions in Experimental Parkinsonism
L. I. Amanda Aguilar García·Donají Chi-Castañeda·Iraís Viveros-Martínez·Mario E. Valerio-Nolasco·Cristofer Zárate-Calderón·Luis Beltrán-Parrazal·Gerardo Marín
Parkinsonian symptoms such as tremors, rigidity, bradykinesia, and postural instability typically arise from basal ganglia dysfunction, but growing evidence suggests cerebellar circuits also play a key role. Here, we investigated multiunit activity (MUA) in the inferior olive (IO), dentate nucleus (DN), and Crus II of the cerebellum in a rat model of tract lesion-induced parkinsonism triggered by ventrolateral striatum (VLS) injury. Thirty-six male Wistar rats were divided into a Lesion group an