The carrying capacity for free fatty acids in plasma is exceedingly high in mammals, and this may be a liability for human metabolic health

As the need to mobilize fuel from adipose tissue changes across a day, such as during the transition from the postprandial to postabsorptive state, the rate of lipolysis is accelerated to mobilize triacylglycerol from adipose tissue in the form of free fatty acids (FFAs) and glycerol. Following export of FFAs from the cell, these hydrophobic molecules face an aqueous environment in blood, where FFA carrier proteins promote their solubility. Plasma FFA carrier proteins, such as albumin, play an i