Workplace abuse against nurses remains a persistent issue within healthcare systems globally. Nurses face verbal, emotional, physical, and sexual abuse from patients, relatives, and colleagues, often with limited institutional protection. This study aims to (a) explore how general nurses in medical wards experience and respond to workplace abuse; (b) examine their coping responses to workplace abuse using Lazarus and Folkman’s Transactional Theory of Stress and Coping; and (c) address theoretical gaps in existing literature on nurse abuse. An ethnographic approach was employed in a district hospital in Ghana. Data was collected from 32 participants through participant observation, in-depth interviews, and informal conversations with general nurses working in medical wards. Thematic network analysis was used in the analysis. Verbal abuse was often normalized and underreported, while emotional, physical, and sexual abuse were appraised as harmful. In response to institutional inaction, nurses employed coping strategies such as emotional distancing, confrontation, avoidance, humor, and informal peer support. Many nurses experienced burnout, emotional detachment, job dissatisfaction, and a decline in professional commitment. Workplace abuse in general medical wards is pervasive and inadequately addressed. There is a need for institutional reforms, including transparent reporting mechanisms, protective policies, and accessible psychosocial support.