Cellular Prion Protein Engages the N -Methyl- d -Aspartate Receptor through N- and C-Terminal Domains

Nonpathogenic cellular prion protein (PrP^C) is expressed by neurons and other cells, regulating neurite outgrowth, cell survival, myelin maintenance, and immunity, yet the PrP^C-protein interaction network and signaling pathways that underlie PrP^C function remain incompletely understood. PrP^C is glycophosphatidylinositol-anchored in lipid rafts and reportedly interacts with membrane-bound proteins at the cell surface, including the N-methyl-d-asp