Tetrapodal zinc oxide (T-ZnO) represents a distinctive ZnO architecture, characterized by a central core and four tetrahedrally arranged monocrystalline arms. Beyond its role as a conventional particle, T-ZnO is increasingly recognized as a microscopic building block whose three-dimensional geometry governs tightly coupled multiphysics properties. This review critically examines the structural lifecycle of T-ZnO across multiple length scales. We evaluate scalable synthesis methodologies and comp