TBP regulates transposable element expression in early mouse embryos
Clara Hermant·Maria-Elena Torres-Padilla·Natasha Jansz·Tsunetoshi Nakatani·Camille Noll·Tamás Schauer·Antoine Canat·Mrinmoy Pal·Marlies E. Oomen·Carlos Michel Mourra-Díaz
The activation of the embryonic genome is a crucial step in development. In addition to thousands of genes, many transposable elements (TEs) are robustly transcribed during early mammalian development. However, their transcriptional regulators remain largely unexplored. Here, we set out to identify transcription factors regulating the expression of TEs from the LINE, SINE and ERVL families during mouse preimplantation development. In particular, the MaLR family are the most abundant ERVL in the