176eP Impact of PD-L1 status on the development of cutaneous immune-related adverse events in non-small cell lung cancer patients receiving immunotherapy
A. Yaakobson·Walid Shalata·Abed Agbarya·Amichay Meirovitz·Fahed Abu Salamah·I. Gothelf·Y. Malek·Ibrahim Alatawneh·Y. Valdman-Grinshpoun·Yulia Dudnik
in vitro/in vivo) tracked via fluorescence imaging/FCM.Tumor tissues underwent scRNA-seq and bioinformatic analysis.Human MPE samples from lung cancer patients yielded autologous MW-TMPs, tested in 3D spheroids and zebrafish PDX models.Results: This method yields more MW-TMPs with lower nucleic acid content than UV-TMPs.MW-TMPs are HMGB1-enriched and potently induce ICD in tumor cells.In lung adenocarcinoma models, MW-TMPs showed superior antitumor activity by reprogramming the immunosuppressive