67P Full device assessment of TROP2 normalized membrane ratio in non-small cell lung carcinoma using a computational pathology algorithm in real-world laboratories
Fernando Lopez-Rios·L.J. Inge·Charalambos Solomides·Claire Bléchet·L. Bubendorf·D. Bryant·N. Fusco·P. Joubert·M. Hanna·M. Salto-Tellez·L.C. Heukamp·Anja C. Roden·Luiza Moore
Trophoblast cell surface antigen 2 (TROP2) is a recognized therapeutic target in non-small cell lung carcinoma (NSCLC). The normalized membrane ratio (NMR) is a quantitative measure of TROP2 immunohistochemical (IHC) expression generated by the TROP2 (EPR20043) NSCLC RUO (research use only) algorithm under pathologist supervision. NMR has emerged as a potential predictive score for assessing NSCLC patient response to a TROP2-targeting antibody-drug conjugate (ADC). Here we build on previous data