This study aims to determine the effects of feeding, management, and reproductive strategies used to reduce age at first calving (AFC) on production and reproductive performance through meta-analytic methods. A literature search using 3 search engines was conducted to identify prospective studies that evaluated AFC for data extraction. Inclusion criteria included specific dairy breeds, a treatment group with an AFC below 26 mo of age, and prospective enrolment of heifers. There were few prospective studies suitable for meta-analysis, with 16 studies containing 35 appropriate experiments. There was substantial heterogeneity likely due to differences in study design and interventions used to induce an AFC difference. Outcomes were assessed using classical multilevel random effects meta-analytic models with standard mean difference, effect sizes, or risk ratios being evaluated where appropriate. Meta-regression was performed using the difference in age at first calving. There was a loss of production for first lactation milk (-2.06 L/d of earlier calving), fat (-0.12 kg/d of earlier calving), and protein (-0.08 of kg/d earlier calving) yield for heifers calving at a younger age than their peers. There were no differences in second and third lactation milk yield, calving difficulty, heifer reproductive performance, survival to calving, and survival to the end of first lactation. While the production in first lactation is decreased, this may be offset by fewer days to first calving without compromising the heifers' ability to calve, become pregnant for the first time, or survive to the end of first lactation. Given the lack of prospective studies, more randomized controlled experiments over multiple lactations, including health, production, and reproductive data, are needed to evaluate this topic further.

