Background Although US-guided intranodal lymphangiography has enabled targeted visualization and intervention for lymphatic leaks, current interstitial approaches, such as MR lymphangiography, have substantial drawbacks. A simpler technique for pedal lymphangiography is required. Purpose To evaluate the feasibility, safety, and image quality of rapid interstitial digital subtraction lymphangiography (DSLA) involving intradermal injection of iodinated contrast media in a porcine model. Materials