A HHEX/IKKα positive feedback loop promotes intestinal inflammation
Zhebin Hua·Peng Du·Weijun Ou·Zhujiang Dai·Wenjun Ding·Wenbo Tang·Chen-Ying Liu·Yaosheng Wang·YingWei Chen·Zhuoyue Fu·Fangyuan Liu·Weimin Xu·Zhongchuan Wang·Yiqing Yang·Wensong Ge
The dynamic assembly and regulation of the IκB kinase (IKK) complex in the NF-κB pathway are central to the pathogenesis and progression of inflammatory bowel disease (IBD). We recently reported that the transcription factor hematopoietically-expressed homeobox (HHEX) promotes colitis-associated colorectal cancer, but the potential role of HHEX in intestinal inflammation remains uncharacterized. Here, we found that HHEX is upregulated in inflamed colons in a colitis mouse model and in clinical I