G protein-coupled receptors (GPCRs) represent one of the most important drug target families, yet comprehensive and standardized GPCR-ligand interaction data remain fragmented across multiple resources. Here, we present GLASS2, a substantially expanded and methodologically enhanced database of GPCR-ligand associations. By integrating data from major pharmacological databases with a large language model (LLM) powered text-mining pipeline applied to PubMed literature, GLASS2 delivers a 72% increas