Amyloid fibril polymorphism: Structural mechanisms of assembly and the links to disease

Amyloid fibrils are involved in devastating conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and systemic amyloidosis. They exhibit polymorphism, meaning that a single protein sequence can adopt different amyloid folds that vary with time and self-assembly conditions. Polymorphism confounds structure-based drug design and raises fundamental questions regarding why particular fibril structures form and how they cause disease. Here, we highlight the latest advance