Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD) but its neural mechanisms remain poorly understood. A mechanistic understanding requires precise characterization of functional responses to various stimulation conditions within the same individual. Here we use 3-T magnetic resonance imaging (MRI)-compatible DBS and precision imaging to collect extensive data from 14 patients with PD who received DBS. Across five timepoints spanning 1 year, each patient underwen
Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans
Jianxun Ren·Hesheng Liu·Lunhao Shen·Wen Zhang·Jing Zhang·Dantong Liu·Yiming Liu·Xiaoxuan Fu·Changgeng He·Shujun Xu·Yilin Yin·Danhong Wang·Shenshen Li·Changqing Jiang·Luming Li·Fangang Meng·Yi Guo·Feng Zhang·Yang Long·Jianting Huang·Louisa Dahmani
