Methylthioadenosine-driven rewiring of sulfur assimilation lowers the methyl index and fertility in Arabidopsis
Benjamin J. M. Tremblay·Barbara A. Moffatt·Barbara A. Katzenback·Rüdiger Hell·John M. Steele·Saeer A. Adeel·Maye Saechao·Eric Andrianasolo·Annika Traa·Nilanth Yogadasan·Yihan Dong·Markus Wirtz·Ishari Waduwara-Jayabahu
The tight coordination of sulfur metabolism and growth regulation is predicated upon nutrient availability. Central to this balancing act is the utilization of cysteine (Cys) for the formation of methionine (Met) and S-adenosylmethionine (SAM). Plants that are severely deficient in regenerating Met due to reduced methylthioadenosine (MTA) nucleosidase activity experience numerous developmental abnormalities. Here, we assess the developmental, metabolic, and regulatory effects associated with dec