Echocardiographic high-output heart failure is associated with worse survival among patients with myelofibrosis
Orly Leiva·Gabriela Hobbs·Yasmeen Murtaza·Stanley Swat·Michelle Lee·Steven Soo·Victor You·Olivia C Liu·Olatoyosi Odenike·Jeanne DeCara·Mark Belkin·Justin Kahla·Anand Patel·Andrew Palmer·Joan How·Leo Gozdecki·Manreet Kanwar
Myelofibrosis (MF) is a type of myeloproliferative neoplasm (MPN) that is associated with significant morbidity and mortality including progression to acute leukemia and cardiovascular disease (CVD). High-output heart failure (HOHF) has been previously associated with MF, though its impact on outcomes is unknown. To investigate the impact of HOHF on outcomes among patients with MF. This was a multicenter retrospective cohort study of MF patients from 2010-2024 with ≥ 1 transthoracic echocardiogr