Evaluation of cellular reaction in brain tissue to platinum coil used in cranial aneurysm treatment

Abstract Background This study aimed to evaluate the histomorphological cellular and fibrotic responses in rat brain tissue following direct placement of platinum coils, simulating potential coil protrusion or extravasation scenarios encountered during endovascular treatment of ruptured intracranial aneurysms. Methods A burr hole was made in the biparietal bone region of 40 Winstar albino rats to pass through the dura and pia mater, and a platinum coil was placed in the interhemispheric area. Th