Pseudomonas aeruginosa is an opportunistic pathogen with a complex regulatory network controlling its physiology and virulence. A key component of this network is PsrA, a TetR-family transcriptional regulator initially identified as an activator of rpoS. PsrA participates in multiple processes, including stress responses, fatty acid metabolism, quorum sensing, and secretion-mediated mechanisms such as the type III secretion system (T3SS). Depending on promoter context and environme