Integrated Phenotypic and Genotypic Drug Susceptibility Profiling of Mycobacterium tuberculosis Reveals High Burden of Multidrug Resistance in Northwest Nigeria

Tuberculosis (TB) drug resistance remains a major public health challenge in Northwest Nigeria, undermining effective disease control and treatment outcomes. This study aimed to assess the genotypic and phenotypic drug susceptibility patterns of Mycobacterium tuberculosis isolates from patients attending TB Reference Centres, with particular focus on first-line, second-line, repurposed, and new anti-TB drugs. A cross-sectional design was employed involving 503 presumptive TB cases. MTB detection