Evolution-Resistant Antibiotics: AI-Designed Drugs and Adaptive Treatment Protocols

Abstract: This study investigates evolution-resistant anti-biotic strategies by integrating AI-assisted drug discovery with adaptive treatment protocols designed to suppress or redirect resistance evolution. The foundational premise is that antimicrobial resistance (AMR) is simultaneously a molecular design problem—requiring new chemotypes and targets—and a dynamical control problem—requiring dosing and sequencing policies that reduce selection for resistant subpopulations. The manuscript theref