Plasticity in the structure and assembly of proteasomes

Proteasomes are large multisubunit protease complexes found in all domains of life, where they execute regulatory and quality control degradation critical for organismal health. The canonical form of the proteasome, known as the 26S proteasome, consists of a 28-subunit barrel-shaped proteolytic core particle (CP) that is capped on its barrel ends by the 19-subunit regulatory particle (RP). The RP recognizes and captures substrates destined for degradation, mechanically unfolds them using energy