Together, our findings suggest that the TWEAK/NF-κB/STAT3 axis represents an attractive target to tune inflammatory stroma/monocyte crosstalk.
TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signaling
Carlos Matellan·Mario C. Manresa·Bella Raphael·Katie Doogan·Stephen D. Thorpe·Carol M. Aherne·C Bauset·Calum C. Bain·Méabh B. Ní Chathail·Ciarán Kennedy·Cian Ohlendieck·Associate Professor Helen M Roche·Gareth R. Jones·Des C Winter·Glen Doherty·Sarah Balfe·Mary Nwaeziegwe