Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinson’s disease mouse model by modulating gut microbiota dysbiosis and inhibiting the NLRP3 signaling pathway

In conclusion, B. coprocola treatment can improve motor deficits, neuroinflammation, and intestinal function in the rotenone-induced PD mouse model. The effects are associated with microbiota remodeling, regulation of macrophage polarization, and inhibition of the NLRP3 inflammasome pathway. Acetate and butyrate, key metabolites of B. coprocola, might play an important role in promoting M2 macrophage polarization through FFAR2/3 receptors.