A Comprehensive Systematic Review of The Relationship Between Excessive Analgesic Use and Migraine Chronicity

Introduction: Medication overuse headache (MOH) is a significant complication in migraine management, where excessive use of acute analgesics paradoxically leads to increased headache frequency and chronicity. Understanding the bidirectional relationship between analgesic overuse and the transformation from episodic to chronic migraine (CM) is crucial for developing effective treatment strategies. This systematic review synthesizes evidence on this relationship and evaluates the efficacy of vari