Phagosome maturation during fungal infection

The phagosome is a dynamic organelle whose function is defined by engulfment and elimination of particles, including debris, dead cells, and foreign material such as invading pathogens. To effectively contain, kill, and degrade pathogens, the phagosome undergoes highly coordinated maturation through interaction with proteins, second messengers, and other organelles in the endocytic pathway. This process involves a progressive decrease in luminal pH as the phagosome fuses with other endocytic ves