Senescence-driven pathogenesis in chronic lung diseases: from mechanistic insights to translational approaches

Chronic lung diseases (CLDs) include a variety of disorders of the pulmonary vasculature and alveolar compartments, and they have become a considerable global health challenge due to their high morbidity and limited therapeutic options. Increasing evidence shows that cellular senescence, an irreversible cell-cycle arrest accompanied by altered secretory activity and resistance to apoptosis, plays a crucial role in the onset and progression of CLDs. One of the major consequences of senescence-ass